Introduction: The Renin-Angiotensin System (RAS) has emerged as being related to
vascular disease. Recently the RAS has been associated with obesity, diabetes, and even cancer.
Objective: This review and Bioinformatics analyses focuses on the investigation of Angiotensinconverting
enzymes (ACE and ACE2) as therapeutical targets for Malignant Epithelial Neoplasia,
specifically for Oral Squamous Cell Carcinoma (OSCC).
Conclusion: The literature review and Bioinformatics analyses showed that ACE and ACE2 are
interesting targets for OSCC treatment. Studies involving RAS and OSCC should be encouraged
for experimental validation.