Angiotensin-Converting Enzymes (ACE and ACE2) as Potential Targets for Malignant Epithelial Neoplasia: Review and Bioinformatics Analyses Focused in Oral Squamous Cell Carcinoma

Author(s): Carlos Alberto de Carvalho Fraga, Lucyana Conceicao Farias, Kimberly Marie Jones, Alfredo Mauricio Batista de Paula, Andre Luiz Sena Guimaraes*

Journal Name: Protein & Peptide Letters

Volume 24 , Issue 9 , 2017

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Graphical Abstract:


Introduction: The Renin-Angiotensin System (RAS) has emerged as being related to vascular disease. Recently the RAS has been associated with obesity, diabetes, and even cancer.

Objective: This review and Bioinformatics analyses focuses on the investigation of Angiotensinconverting enzymes (ACE and ACE2) as therapeutical targets for Malignant Epithelial Neoplasia, specifically for Oral Squamous Cell Carcinoma (OSCC).

Conclusion: The literature review and Bioinformatics analyses showed that ACE and ACE2 are interesting targets for OSCC treatment. Studies involving RAS and OSCC should be encouraged for experimental validation.

Keywords: Head and neck cancer, obesity, Angiogenesis, ACE, Ang 1-7, angiotensin-converting enzyme.

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Article Details

Year: 2017
Page: [784 - 792]
Pages: 9
DOI: 10.2174/0929866524666170815161621
Price: $65

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