Glycan Phosphorylases in Multi-Enzyme Synthetic Processes

Author(s): Giulia Pergolizzi, Sakonwan Kuhaudomlarp, Eeshan Kalita, Robert A. Field*

Journal Name: Protein & Peptide Letters

Volume 24 , Issue 8 , 2017

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Graphical Abstract:


Glycoside phosphorylases catalyse the reversible synthesis of glycosidic bonds by glycosylation with concomitant release of inorganic phosphate. The equilibrium position of such reactions can render them of limited synthetic utility, unless coupled with a secondary enzymatic step where the reaction lies heavily in favour of product. This article surveys recent works on the combined use of glycan phosphorylases with other enzymes to achieve synthetically useful processes.

Keywords: Phosphorylase, disaccharide, α-glucan, cellodextrin, high-value products, biofuel.

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Article Details

Year: 2017
Published on: 11 August, 2017
Page: [696 - 709]
Pages: 14
DOI: 10.2174/0929866524666170811125109

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