Association between Apo B Levels in Mothers and in their Pre-school Age Offspring

Author(s): Valeria Hirschler*, Maximiliano Martin, Karen Oestreicher, Claudia Molinari, Laura Boero, Walter Tetzlaff, Fernando Brites

Journal Name: Cardiovascular & Hematological Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents

Volume 15 , Issue 1 , 2017

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Graphical Abstract:


Objective: The study aims to determine the association between apo B levels in mothers and their pre-school offspring.

Methods: Anthropometric measurement (e.g. BMI), lipids, lipoproteins, and apolipoproteins (e.g. apo B) levels in mothers and their children were obtained in November 2015 in Buenos Aires.

Results: Eighty-four children (42M) aged 5.3±1.6 years and their mothers aged 33.8±7.2 years were examined. The prevalence of overweight was 39.2 % (33) in mothers and 22.6 % (19) in children, and the prevalence of obesity was 38.1% (32) in mothers and 10.7% (9) in children. Multiple linear regression analysis showed that maternal apo B levels were associated with apo B levels in their offspring, adjusted for confounding variables (Beta=0.29; p=0.03; R2=0.25). Furthermore, offspring born to mothers with high apo B levels were six times likelier to have high apo B levels (OR), 5.7; (95% CI 1.3-25.5).

Conclusion: This study suggests that maternal apo B levels were significantly associated with apo B concentration in their pre-school age children.

Keywords: Cardiovascular disease, dyslipidemia, apo B, pre-school children, mothers, BMI.

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Article Details

Year: 2017
Published on: 11 August, 2017
Page: [62 - 68]
Pages: 7
DOI: 10.2174/1871525715666170811112356
Price: $65

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