Molecular Bases of Neurodegenerative Disorders of the Retina

Molecular Bases of Neurodegenerative Disorders of the Retina

This book focuses on the physiology and molecular biology of the front and back regions of the eye. Specifically, the chapters of this book cover topics that explain currently less understood aspects ...
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Rhodopsin-Regulated Grb14 Trafficking to Rod Outer Segments: Functional Role of Grb14 in Photoreceptors

Pp. 101-108 (8)

Raju V.S. Rajala

Abstract

Growth factor receptor-bound protein 14 (Grb14) belongs to the Grb7 family. It is an adapter molecule, lacking any intrinsic enzyme activity, but mediates protein-protein and protein-lipid interactions. In photoreceptors, Grb14 undergoes a rhodopsin-dependent translocation from the inner segments to the outer segments. In photoreceptors, Grb14 undergoes a light-dependent tyrosine phosphorylation and protects the insulin receptor (IR) phosphorylation, which is neuroprotective. Outersegment- localized Grb14 also modulates the activity of the cyclic nucleotide gated (CNG) chancel. Thus, Grb14 plays a key role in receiving signals from rhodopsin, and translocating to outer segments, where it regulates IR and CNG channel activities. The present study supports the idea that rhodopsin regulates non-canonical signaling pathways in photoreceptor cells.

Keywords:

CNG channel, Grb14, Insulin receptor, PTP1B, Rhodopsin, Rod outer segments, Tyrosine phosphorylation.

Affiliation:

Departments of Ophthalmology, Physiology, and Cell Biology, University of Oklahoma Health Sciences Center, and Dean A. McGee Eye Institute, Oklahoma City, Oklahoma 73104, USA.