Inositol Phosphatases in Retinal Ciliary Disorder
Pp. 39-53 (15)
Cathleen Wallmuth, Na Luo and Yang Sun
Phosphoinositides are phospholipids that regulate signal transduction,
endocytosis, and protein trafficking. Each phosphoinositide has a unique pattern of
distribution within cellular compartments and is tightly regulated by inositol kinases
and phosphatases localized within a specific membrane compartment. Inositol
polyphosphate 5-phosphatases regulate phosphoinositide levels and are implicated in
human diseases, such as Lowe syndrome and Joubert syndrome. Here we review the
pertinent findings of the roles of 5-phosphatases in cilia function and signaling.
Cilia, INPP5E, Joubert syndrome, Lowe syndrome, OCRL.
Indiana University School of Medicine, 1160 W. Michigan St., Indianapolis, IN 46202, USA