Molecular Bases of Neurodegenerative Disorders of the Retina

Molecular Bases of Neurodegenerative Disorders of the Retina

This book focuses on the physiology and molecular biology of the front and back regions of the eye. Specifically, the chapters of this book cover topics that explain currently less understood aspects ...
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Ciliary Trafficking in Vertebrate Photoreceptors

Pp. 1-15 (15)

Hemant Khanna

Abstract

Cilia are microtubule-based extensions of the plasma membrane of cells. These extensions detect extrinsic cues that are crucial for carrying out a myriad of developmental and homeostatic signaling cascades. Cilia have evolved diverse means to mediate signaling cascades in a cell-type specific manner. In this article, I have summarized the conserved mechanisms of formation of cilia and their structural and functional specialization for light detection.

Keywords:

Basal body, Cilia, Photoreceptor, Retina.

Affiliation:

Department of Ophthalmology, UMASS Medical School, Worcester, MA, USA