Peripheral Artery Disease (PAD), a common vascular disease, has been associated with increased
Cardiovascular (CV) morbidity and mortality as well as all-cause death. Type 2 Diabetes Mellitus
(T2DM) predisposes to PAD development. In T2DM patients, PAD further increases the risk for CV
disease and death as well as foot morbidity and microvascular complications.
The present narrative review discusses the role of oxidative stress and inflammation in the pathophysiology
of PAD with or without the presence of T2DM. The effects of lifestyle measures (i.e. diet, physical
activity and smoking cessation) and drug treatment on markers of oxidative stress and inflammation
are also considered. Further research should establish the clinical implications of such effects as well as
the clinical use of antioxidants and anti-inflammatory drugs in PAD.