Title:The Application of the Cold Atmospheric Plasma-Activated Solutions in Cancer Treatment
VOLUME: 18 ISSUE: 6
Author(s):Dayun Yan*, Jonathan H. Sherman and Michael Keidar*
Affiliation:Department of Mechanical and Aerospace Engineering, The George Washington University, Science & Engineering Hall, 800 22nd Street, NW, Room 3550, Washington, DC 20052, Neurological Surgery, The George Washington University, Foggy Bottom South Pavilion, 22nd Street, NW, 7th Floor, Washington, DC 20037, Department of Mechanical and Aerospace Engineering, The George Washington University, Science & Engineering Hall, 800 22nd Street, NW, Room 3550, Washington, DC 20052
Keywords:Plasma, cold atmospheric plasma, cancer cells, cancer treatment, reactive nitrogen species, reactive oxygen species.
Abstract:Background: Over the past five years, the cold atmospheric plasma-activated solutions (PAS) have
shown their promissing application in cancer treatment. Similar as the common direct cold plasma treatment,
PAS shows a selective anti-cancer capacity in vitro and in vivo. However, different from the direct cold atmospheric
plasma (CAP) treatment, PAS can be stored for a long time and can be used without dependence on a
CAP device. The research on PAS is gradually becoming a hot topic in plasma medicine.
Objectives: In this review, we gave a concise but comprehensive summary on key topics about PAS including
the development, current status, as well as the main conclusions about the anti-cancer mechanism achieved in
past years. The approaches to make strong and stable PAS are also summarized.
