The Application of the Cold Atmospheric Plasma-Activated Solutions in Cancer Treatment

Author(s): Dayun Yan*, Jonathan H. Sherman, Michael Keidar*

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 18 , Issue 6 , 2018

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Graphical Abstract:


Background: Over the past five years, the cold atmospheric plasma-activated solutions (PAS) have shown their promissing application in cancer treatment. Similar as the common direct cold plasma treatment, PAS shows a selective anti-cancer capacity in vitro and in vivo. However, different from the direct cold atmospheric plasma (CAP) treatment, PAS can be stored for a long time and can be used without dependence on a CAP device. The research on PAS is gradually becoming a hot topic in plasma medicine.

Objectives: In this review, we gave a concise but comprehensive summary on key topics about PAS including the development, current status, as well as the main conclusions about the anti-cancer mechanism achieved in past years. The approaches to make strong and stable PAS are also summarized.

Keywords: Plasma, cold atmospheric plasma, cancer cells, cancer treatment, reactive nitrogen species, reactive oxygen species.

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Article Details

Year: 2018
Published on: 12 November, 2018
Page: [769 - 775]
Pages: 7
DOI: 10.2174/1871520617666170731115233
Price: $65

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