Title:Neuroprotection in Hypoxic-Ischemic Brain Injury Targeting Glial Cells
VOLUME: 23 ISSUE: 26
Author(s):Maria Ines Herrera*, Sofia Mucci*, George E. Barreto, Rodolfo Kolliker-Frers and Francisco Capani*
Affiliation:Laboratorio de Citoarquitectura y Plasticidad Neuronal, Facultad de Medicina, Instituto de Investigaciones Cardiologicas Prof. Dr. Alberto C. Taquini (ININCA), UBA-CONICET, CABA, Buenos Aires, Laboratorio de Citoarquitectura y Plasticidad Neuronal, Facultad de Medicina, Instituto de Investigaciones Cardiologicas Prof. Dr. Alberto C. Taquini (ININCA), UBA-CONICET, CABA, Buenos Aires, Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana Bogota, D.C., Colombia, Laboratorio de Citoarquitectura y Plasticidad Neuronal, Facultad de Medicina, Instituto de Investigaciones Cardiologicas Prof. Dr. Alberto C. Taquini (ININCA), UBA-CONICET, CABA, Buenos Aires, Laboratorio de Citoarquitectura y Plasticidad Neuronal, Facultad de Medicina, Instituto de Investigaciones Cardiologicas Prof. Dr. Alberto C. Taquini (ININCA), UBA-CONICET, CABA, Buenos Aires
Keywords:brain injury, hypoxia-ischemia, pharmacological treatments, glial cells, neuroprotection
Abstract:Brain injury constitutes a disabling health condition of several etiologies. One of the major causes of
brain injury is hypoxia-ischemia. Until recently, pharmacological treatments were solely focused on neurons. In
the last decades, glial cells started to be considered as alternative targets for neuroprotection. Novel treatments for
hypoxia-ischemia intend to modulate reactive forms of glial cells, and/or potentiate their recovery response. In
this review, we summarize these neuroprotective strategies in hypoxia-ischemia and discuss their mechanisms of
action.
