Abstract
Background: The detection of biological molecules referred as biomarkers in biological fluids is fundamental in clinical analysis because it permits to discriminate between healthy and ill individuals and to evaluate the progress of a disease. The development of immunosensors for the detection and monitoring of biomarkers is currently a major area of research and, as more markers are discovered and their role in disease becomes better understood, this will continue to grow.
Methods: We report the research progresses of electrochemical immunosensor applied in clinical analysis that have been published in the last three years.
Results: The emphasis of this review is on the advances of the electrochemical immunosensors for detection and monitoring of cancerous, cardiovascular and neurological diseases. An immunosensor overview was presented as well as the biomarkers and biosensing systems currently used to detect the onset and monitor the progression of the mentioned diseases.
Conclusions: Electrochemical biosensors focusing on a vast repertoire of analytes are now becoming one of the most widely explored scientific fields. This is due to their enormous potential in clinical diagnosis and biological process monitoring.
In the near future, with the development of transducer technology, nano-sized material technology, and biomolecules engineering technology, biosensors should be powerful tools in several analytical areas.
Keywords: Immunosensors, biomarker, cancer, cardiac, autoimmune, electrochemical.
Current Medicinal Chemistry
Title:Electrochemical Immunosensors for Disease Detection and Diagnosis
Volume: 25 Issue: 33
Author(s): Oana Hosu, Giulia Selvolini, Cecilia Cristea and Giovanna Marrazza*
Affiliation:
- Department of Chemistry ,Italy
Keywords: Immunosensors, biomarker, cancer, cardiac, autoimmune, electrochemical.
Abstract: Background: The detection of biological molecules referred as biomarkers in biological fluids is fundamental in clinical analysis because it permits to discriminate between healthy and ill individuals and to evaluate the progress of a disease. The development of immunosensors for the detection and monitoring of biomarkers is currently a major area of research and, as more markers are discovered and their role in disease becomes better understood, this will continue to grow.
Methods: We report the research progresses of electrochemical immunosensor applied in clinical analysis that have been published in the last three years.
Results: The emphasis of this review is on the advances of the electrochemical immunosensors for detection and monitoring of cancerous, cardiovascular and neurological diseases. An immunosensor overview was presented as well as the biomarkers and biosensing systems currently used to detect the onset and monitor the progression of the mentioned diseases.
Conclusions: Electrochemical biosensors focusing on a vast repertoire of analytes are now becoming one of the most widely explored scientific fields. This is due to their enormous potential in clinical diagnosis and biological process monitoring.
In the near future, with the development of transducer technology, nano-sized material technology, and biomolecules engineering technology, biosensors should be powerful tools in several analytical areas.
Export Options
About this article
Cite this article as:
Hosu Oana, Selvolini Giulia, Cristea Cecilia and Marrazza Giovanna *, Electrochemical Immunosensors for Disease Detection and Diagnosis, Current Medicinal Chemistry 2018; 25 (33) . https://dx.doi.org/10.2174/0929867324666170727104429
DOI https://dx.doi.org/10.2174/0929867324666170727104429 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Allosteric Regulators of the Proteasome: Potential Drugs and a Novel Approach for Drug Design
Current Medicinal Chemistry Interferon: Cellular Executioner or White Knight?
Current Medicinal Chemistry Hepatic Manifestations in Juvenile Systemic Lupus Erythematosus
Recent Patents on Inflammation & Allergy Drug Discovery Stem Cell-Based Immunomodulation in Type 1 Diabetes: Beyond the Regenerative Approach
Current Pharmaceutical Design T Cell-Activated Signaling Pathways and Locally Produced Cytokines as Potential Targets in Celiac Disease
Current Drug Targets Triggering of Apoptosis and Pro-Inflammatory Cytokines in NK Cells: Regulation by Cyclosporin A
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Mast Cells as Target in Cancer Therapy
Current Pharmaceutical Design The Rationale for Comparative Studies of Accelerated Atherosclerosis in Rheumatic Diseases
Current Vascular Pharmacology Oral Tolerance in the Treatment of Rheumatoid Arthritis
Current Drug Targets - Inflammation & Allergy Peptides Against Autoimmune Neurodegeneration
Current Medicinal Chemistry Biologics in Inflammatory Immune-mediated Systemic Diseases
Current Pharmaceutical Biotechnology Combinatorial Application of Multiple High-throughput Biotechnologies for the Study of Autoimmune Diseases
Current Pharmaceutical Analysis The Medical Functions of Probiotics and Their Role in Clinical Nutrition
Current Nutrition & Food Science The Role of Anaphylatoxins C3a and C5a in Regulating Innate and Adaptive Immune Responses
Inflammation & Allergy - Drug Targets (Discontinued) Vitamin D Receptor as a Drug Discovery Target
Mini-Reviews in Medicinal Chemistry Molecular Mimicry in Autoimmune Neurological Disease after Viral Infection
Current Medicinal Chemistry Role of Positron Emission Tomography for Central Nervous System Involvement in Systemic Autoimmune Diseases: Status and Perspectives
Current Medicinal Chemistry Mechanism by which Regulatory Rheumatoid Factor Prevents Experimental Autoimmune Encephalomyelitis
Endocrine, Metabolic & Immune Disorders - Drug Targets The Effects of Dehydroepiandrosterone (DHEA) in the Treatment of Depression and Depressive Symptoms in Other Psychiatric and Medical Illnesses: A Systematic Review
Current Drug Targets Functional Genome and Proteome Analyses of Cutaneous Autoimmune Diseases
Current Pharmaceutical Design