Synthesis and Biological Screening of N,N’-bis Disubstituted Adipic Acid Thioureas

Author(s): Aneela Maalik*, Sadia Hameed, Huma Aslam Bhatti, Abdur Rauf, Syed Majid Bukhari, Nighat Fatima, Hummera Rafique, Ehsan Ullah Mughal, Amara Mumtaz*

Journal Name: Current Pharmaceutical Analysis

Volume 14 , Issue 6 , 2018


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Abstract:

Background: Synthesis of substituted N’-aryl-N’-adipic acid thiourea (1-7) was, carried out adipic acid chlorides with potassium thiocynate in situ produced isocyanate followed by reflux with substituted anilines in dry acetone till the completion of reaction.

Methods: Structure elucidation of all the synthesized compounds was carried out by UV-Vis, FT-IR and 1HNMR analysis. All the synthesized compounds were evaluated for their biological screening by subjecting to antimicrobial and antioxidant activities.

Conclusion: In case of antibacterial screening most significant results were obtained by compound 7 having fluoro group at the para position with 16.5±1.0 zone of inhibition against methicilline resistant S. aureus (MRSA 09) while no activity was observed in case of antifungal activities. Compound 7 also showed significant antioxidant activities in DPPH assay with percent scavenging values of 63.51±.8.3.

Keywords: Antimicrobial, antioxident, cytotoxic, thioureas, adipic acid thiourea, potassium thiocynate.

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Article Details

VOLUME: 14
ISSUE: 6
Year: 2018
Published on: 16 September, 2018
Page: [618 - 621]
Pages: 4
DOI: 10.2174/1573412913666170726122027
Price: $65

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