Background: Synthesis of substituted N’-aryl-N’-adipic acid thiourea (1-7) was, carried out
adipic acid chlorides with potassium thiocynate in situ produced isocyanate followed by reflux with
substituted anilines in dry acetone till the completion of reaction.
Methods: Structure elucidation of all the synthesized compounds was carried out by UV-Vis, FT-IR and
1HNMR analysis. All the synthesized compounds were evaluated for their biological screening by subjecting
to antimicrobial and antioxidant activities.
Conclusion: In case of antibacterial screening most significant results were obtained by compound 7
having fluoro group at the para position with 16.5±1.0 zone of inhibition against methicilline resistant S.
aureus (MRSA 09) while no activity was observed in case of antifungal activities. Compound 7 also
showed significant antioxidant activities in DPPH assay with percent scavenging values of 63.51±.8.3.