Background: The protective value of vaccines to the public has made vaccines among
the major public health prophylactic measures through the entire history. However, there has been
some controversy about their safety; particularly concerns have been rising about febrile seizures
(FS). Vaccination was found to be the second most common cause of FS.
Methods: We research and collect relative online content for reviewing the effects of vaccine in FS.
Results: there is no causal relationship between FS and vaccination. This relationship is complex by
other factors, such as age, genetic inheritance, type of vaccine, combination of different types of
vaccines and the timing of vaccination.
Conclusion: In order to reduce FS after vaccination, it is important to understand the mechanism of
epilepsy and relationship between specific vaccines and FS. Parents should be informed that some
vaccines could be associated with an increased risk of FS, particularly, in children with personal
and family history of FS. Children with genetic epilepsy syndrome are prone to seizures and certain
vaccinations should be avoided in these children. It is highly recommended to choose vaccines with
lower risk of developing FS and to administer these vaccines during the low risk window of immunizations