Background: Thiazoles are promising scaffolds in the area of medicinal and
pharmaceutical chemistry and have accounted to show different pharmacophoric properties.
For the last years, thiazole derivatives have focused too much attention to develop
different new CNS active agents. It has been broadly used to generate diverse therapeutic
agents against various CNS targets. Histamine H3 receptors are seriously involved
in the pathophysiology of numerous disorders of the central nervous system.
Method: The literature survey has been done using different database from peerreviewed
journals. The quality of repossessed papers was evaluated using standard
tools. The details of important papers were described to focus on the potency of thiazole
containing heterocycles with CNS activity.
Result: Eighty nine papers were included in the review indicating thiazole containing
heterocycles with CNS activity. (1) to (30) papers included different thiazole derivatives
impregnated withCNS activity. Different CNS agents have been shown in references
(37) to (56). The remaining papers have been searched for anticonvulsant
agents (57) to (78) and other miscellaneous activities from (79) to (89).
Conclusion: A detailed investigation has been carried out on thiazoles and its derivatives
to judge its efficacy to overcome several CNS disorders. This article covers the
recent updates of thiazole and its derivative with CNS activity already present in literature
and will definitely provide a better platform for the production and development
of potent thiazole based CNS vigorous drugs in near future.