Background: Therapeutic angiogenesis is a clinical intervention for controlled
stimulation and augmentation of neovascularisation in ischemic tissues. Conventional
therapeutic techniques involve proangiogenic factor based induction of host tissue angiogenesis.
In this review, we provide a holistic idea about therapeutic angiogenesis while specifically
highlighting the role of proangiogenic factors as growth factors, peptides, small
molecules and polysaccharides in tissue neovascularisation.
Methods: A detailed search of peer-reviewed literature was carried out with prime focus on
therapeutic angiogenesis and proangiogenic factors. The content of each literature reviewed
in this paper was qualitatively analysed for particulars and relevance to the subject of study.
This work has been distributed under four broad titles, namely, proangiogenic growth factors,
peptides, small molecules and polysaccharides. Also, recent developments pertaining
to proangiogenic factors for therapeutic angiogenesis have been detailed.
Results: A total of 244 literatures have been reviewed from the bibliographic database to
present a conceptual understanding about the importance of proangiogenic factors in
revascularisation of ischemic tissues.
Conclusion: This review focuses on importance of various proangiogenic factors, with reference
to therapeutic angiogenesis. Thorough analysis of clinical data reveals the dearth of a
defined system for proangiogenic growth factor delivery. Designing of a biomaterial based
paradigm for growth factor therapy, might help in enhancing clinical translation of therapeutic