Endogenous Biomarkers to Assess Drug-Drug Interactions by Drug Transporters and Enzymes

Title:Endogenous Biomarkers to Assess Drug-Drug Interactions by Drug Transporters and Enzymes

Volume: 18 Issue: 8

Author(s): T. Thanga Mariappan*, Hong Shen and Punit Marathe

Affiliation:

• Pharmaceutical Candidate Optimization, Biocon Bristol Myers-Squibb R&D Centre (BBRC), Syngene International Limited, Bangalore - 560 099,India

Keywords: Endogenous biomarkers, transporters, enzymes, drug-drug interactions, inhibition, induction.

Abstract: Background: Drug-Drug Interactions (DDI) by modulation of drug transporters or drug metabolizing enzymes are common in multi-drug therapy. DDI potential of any new drug is assessed by conducting separate clinical studies using relevant probe substrates, which involves additional resource and cost. Recently, several endogenous compounds have been evaluated as substrates of transporters and enzymes that could be assessed as part of early clinical trials along with the assessment of drug pharmacokinetics, pharmacodynamics and safety studies. This enables an early readout on potential DDIs avoiding or minimally delaying the conduct of definitive DDI studies until later in clinical development.

Method: This review describes various endogenous biomarkers reported for drug transporters and metabolizing enzymes with their advantages and limitations.

Conclusion: Furthermore, the authors describe strategies to adopt while exploring a new endogenous biomarker, and factors to be considered in selection of biomarkers with the current challenges and opportunities.

Cite this article as:

Mariappan T. Thanga *, Shen Hong and Marathe Punit , Endogenous Biomarkers to Assess Drug-Drug Interactions by Drug Transporters and Enzymes, Current Drug Metabolism 2017; 18 (8) . https://dx.doi.org/10.2174/1389200218666170724110818