Design, Synthesis and Antibacterial Evaluation of Compounds Based on New Benzoxepine-oxime-1,2,3-triazole Hybrid

Author(s): Naveen Kuntala, Jhonsee Rani Telu, Venkanna Banothu, Sridhar Balasubramanian, Jaya Shree Anireddy, Sarbani Pal*

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 18 , Issue 9 , 2018

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Graphical Abstract:


Background: A library of compounds related to the new benzoxepine-oxime-1,2,3-triazole hybrid was created as probable antibacterial agents. Their synthesis involved a Cu-catalyzed azidealkyne cycloaddition (CuAAC) as a key step to construct the desired 1,2,3-triazole ring. Thus the click reaction between the appropriate alkyne containing the benzoxepine-oxime framework with aryl azides afforded the target compounds in good yields.

Method: To assess their antibacterial properties all the synthesized compounds were tested using four bacterial strains consisting of one Gram-positive and three Gram-negative species.

Results & Conclusion: These compounds were generally found to be effective towards gram -ve species and one of them showed selective cytotoxicity against lung cancer cell line.

Keywords: Antibacterial, benzoxepine, oxime, 1, 2, 3-triazole, hybrid, erythromycin.

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Article Details

Year: 2018
Published on: 30 April, 2018
Page: [803 - 809]
Pages: 7
DOI: 10.2174/1389557517666170717123741
Price: $65

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