Natural Steroids and Androgen Antagonists used as Neuroprotection in Common Neurological Disorders

Author(s): David Calderon Guzman, Hugo Juarez Olguin*, Ernestina Hernandez Garcia, Monica Punzo Soto, Mayra Santillan Garcia, Gerardo Barragan Mejia

Journal Name: CNS & Neurological Disorders - Drug Targets
Formerly Current Drug Targets - CNS & Neurological Disorders

Volume 16 , Issue 7 , 2017

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Graphical Abstract:


Background & Objective: Multiple classes of natural products, such as antiandrogens or steroids have been used as antioxidants and anti-inflammatory treatments in neurodegenerative diseases. This paper aims to review current knowledge on these substances and their possible relationship with free radicals as an alternative therapy and prevention of common neurological disorders. An exhaustive review of the neurochemical mechanisms of these substances in the central nervous system of humans and animal models is yet to be undertaken in the literature, particularly regarding their importance and increasing use.

Conclusion: Androgen receptor antagonists act in a different way that may underlie the benefits of natural products, with the expectation that in adults, neurological disorders would respond to natural antiandrogens. We hope that this work would provide valuable insight into the protective and therapeutic roles for natural antiandrogens and steroids in common neurological disorders.

Keywords: Androgens, antagonist, CNS, neurological disorders, neuroprotectors, steroids.

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Article Details

Year: 2017
Page: [763 - 771]
Pages: 9
DOI: 10.2174/1871527316666170714121654
Price: $65

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