Background: Individuals with chronic diseases have persistent pain as the main symptom,
which can often reduce their life quality and functional capacity. The suffering of patients results from
the interaction of aversive perception of pain with physical disability, social and family isolation, financial
worries and fear of mutilation and death. As an individual and subjective phenomenon that involves
many complex aspects, chronic pain should be evaluated and treated in its various components.
Several drugs are currently used, but besides the high cost, they have side effects that are harmful to
patients. Therefore, there is the need to search for new options for pain relief. Natural products as
monoterpenes have been the target of many researchers.
Objective: This systematic review aimed to briefly summarize the knowledge of the analgesic potential
of monoterpenes facing chronic pain.
Results: After a search in PubMed, Lilacs, Scopus and Cochrane, 27 articles were selected, which described
the analgesic potential of 16 monoterpenes for relief of chronic pain.
Conclusion: After analyzing the data, it can be suggested that these compounds are strong candidates
for the treatment of painful states.