Bio-based Material as Medium, Mild and Reusable Catalyst for Paal– Knorr Pyrrole Synthesis with and Without Ultrasonic Irradiation

Author(s): Abha Sharma*, Illa Siva Kalyani, Anam Fatima

Journal Name: Letters in Organic Chemistry

Volume 15 , Issue 3 , 2018

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Background: Pyrrole moiety is found in naturally occurring compounds such as chlorophyll, haem, and vitamin B12 and present in a number of drugs for example atorvastatin, ketorolac, elopiprazole, tolmetin and sunitinib. Various methods have been used for the synthesis of pyrrole derivatives; however, still there is a need for environmentally benign and economic protocol.

Method: We have reported a simple, mild and speedy synthesis of N-substituted 2,5-dimethyl pyrrole derivatives in ‘’GAAS’’ as medium and catalyst at room temperature and under ultrasound irradiation.

Results: This protocol was employed for the synthesis of various 2,5-dimethyl-N-substituted pyrrolederivatives using both aliphatic as well as aromatic amines in short time (2 to 10 minutes)with excellent yield (84-95%) at room temperature and under ultrasonic irradiation. The catalytic system “GAAS’’ was regenerated and reused five times effectively without major loss of activity.

Conclusion: In conclusion, we have developed an eco-friendly, simple, faster, reusable, mild, and efficient protocol for the synthesis of N-substituted pyrrole derivatives. This bio-based protocol is cost-effective and greener methodology for the synthesis of biologically active N-substituted pyrrole derivatives.

Keywords: GAAS, ultrasound, N-substituted pyrrole derivatives, catalyst, organic synthesis, irradiation.

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Article Details

Year: 2018
Published on: 07 February, 2018
Page: [226 - 232]
Pages: 7
DOI: 10.2174/1570178614666170711145253
Price: $65

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