The Role of Oxidative Stress Modulators in Breast Cancer

Title:The Role of Oxidative Stress Modulators in Breast Cancer

Volume: 25 Issue: 33

Author(s): Hande Gurer-Orhan*, Elif Ince, Dilan Konyar, Luciano Saso*Sibel Suzen

Affiliation:

• Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ege University, 35100 Izmir,Turkey

• Department of Physiology and Pharmacology ,Italy

Keywords: Oxidative stress, reactive oxygen species, breast cancer, oxidative stress modulators, melatonin.

Abstract: Background: Latest data from International Agency for Cancer Research shows that breast cancer is the leading cancer site in women and is the leading cause of death among female cancers. Induction of reactive oxygen species (ROS) and oxidative stress as a consequence of impaired balance between prooxidants and antioxidants are suggested to be involved in induction and progression of breast cancer. Cancer cells are found to exhibit higher levels of ROS compared to normal cells. However increased antioxidant defence which balances the oxidative status within the cancer cells suggests that high ROS levels may prevent tumorigenesis via various mechanisms. These contradictory roles of ROS and oxidative stress in breast cancer let scientists investigate potential oxidative stress modulators as anticancer strategies.

Conclusions: In the present review we address the mechanisms of ROS production in breast cancer cells, the role of impaired oxidative status as well as the benefits of introducing oxidative stress modulators in therapeutic strategies in breast cancer. This review is focusing more on melatonin which we have been working on during the last decade. Our data, in accordance with the literature, suggest an important role for melatonin in breast cancer prevention and adjuvant therapy.

Cite this article as:

Gurer-Orhan Hande *, Ince Elif , Konyar Dilan , Saso Luciano *, Suzen Sibel, The Role of Oxidative Stress Modulators in Breast Cancer, Current Medicinal Chemistry 2018; 25 (33) . https://dx.doi.org/10.2174/0929867324666170711114336