Shared Pathophysiology between Depression, Obesity and Metabolic Disturbances: Novel Antidepressant Targets?
Pp. 298-356 (59)
Léa Décarie-Spain, Dominique Matthys and Stephanie E. Fulton
The prevalence of obesity and related metabolic disorders is largely the
result of poor dietary choices and excessive caloric intake. Consumption of palatable,
energy-rich foods can lead to obesity and increase the risk of depression. Depression
not only impairs the quality of life of obese individuals but also increases the
associated risks of obesity and hinders motivation to seek out and adhere to weight loss
strategies. In turn, certain forms of depression are closely linked with overeating,
promoting an adverse cycle of depressed mood, comfort-food seeking and further
weight gain. This chapter provides an overview of the metabolic, immune and neural
processes that accompany increased adiposity and obesity and their impact on mood
and the development of depression. In this context, potential treatments for the
alleviation of depression co-morbid with obesity are discussed.
Anhedonia, Animal models, Cortisol, Depressive-like behaviours,
Diabetes, Diet-induced obesity, Drug treatment, Inflammation, Insulin, Leptin,
Polyunsaturated fatty acids, Reward, Stress.
University of Montreal Hospital Research Center (CRCHUM); Department of Neuroscience, University of Montreal and Montreal Diabetes Research Centre, Montreal, QC, Canada.