Monoamine Oxidase-A: A Valid Target for the Management of Depression
Pp. 126-134 (9)
Bijo Mathew and Jerad Suresh
Monoamine oxidase enzyme has been developed as a valid target for the
treatment of depression. The development of selective and reversible type of
monoamine oxidase-A inhibitors still remains a challenge to medicinal chemists
pursuing the research towards the search of innovative chemotypes for the management
of depressive states. The present chapter focuses on the history of MAO-A inhibitors,
structure and biochemistry of MAO-A. It also covers challenges involved in the drug
development of MAO-A inhibitors.
Adrenaline, Chees effect, Depression, FAD/Dopamine, Inhibitor
binding cavity, MAO-A, MAO-B, Moclobemide, Tranylcypromine.
Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Ahalia School of Pharmacy, Palakkad 678557, Kerala, India.