Research interests on amphibian antimicrobial peptides (AMPs) are currently increasing because
of their capability to combat microorganisms from both terrestrial and aquatic environments,
which are the warehouses of human pathogens. The most remarkable feature of AMPs are their mechanism
of action, primarily targeted to anionic membranes. Researchers have postulated many models to
describe peptide- membrane interaction, which leads to membrane permeation/intracellular targeting.
Despite these models information regarding the relationship between membrane curvature and peptidemembrane
interaction is scarce. This relationship could be clearly depicted using the two-state model
and interfacial activity model. In the review, we discuss in detail the two state and interfacial activity
models and explain the influence of membrane curvature on peptide binding and the membrane interaction
of curvature-sensitive peptides. In addition, the models proposed to explain the mechanism of action
of membrane lytic and non-lytic AMPs are also reviewed.
Keywords: Amphibian host defense peptides, interfacial activity model, membrane curvature, two-state model, saddle-splay
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