An efficient synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives using nanocrystalline
magnesium oxide (nano-MgO) as a catalyst from 2-aminobenzamide and various aldehydes/ketones
under aqueous conditions at room temperature is described. Nano-MgO was synthesized by the precipitation
and hydrothermal treatment of aqueous salt solution as reported previously. The structure of
nano-MgO was characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM)
analysis. Simple conditions, environmentally benign, good to excellent yields and comparatively
shorter reaction times are the advantages of this protocol.
Keywords: 2-Aminobenzamide, aldehyde, 2, 3-dihydroquinazolin-4(1H)-one, green, nano-MgO, water.
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