Title:Expeditious and Green Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones Catalyzed by Nano-MgO
VOLUME: 15 ISSUE: 6
Author(s):Hamzeh Kiyani*, Mohsen Tazari and Fatemeh Ghorbani
Affiliation:School of Chemistry, Damghan University, 36715-41167 Damghan, School of Chemistry, Damghan University, 36715-41167 Damghan, School of Chemistry, Damghan University, 36715-41167 Damghan
Keywords:2-Aminobenzamide, aldehyde, 2, 3-dihydroquinazolin-4(1H)-one, green, nano-MgO, water.
Abstract:An efficient synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives using nanocrystalline
magnesium oxide (nano-MgO) as a catalyst from 2-aminobenzamide and various aldehydes/ketones
under aqueous conditions at room temperature is described. Nano-MgO was synthesized by the precipitation
and hydrothermal treatment of aqueous salt solution as reported previously. The structure of
nano-MgO was characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM)
analysis. Simple conditions, environmentally benign, good to excellent yields and comparatively
shorter reaction times are the advantages of this protocol.
