Background: Heterocycles are the gold mines in medicinal chemistry. Most drugs used in
today's medicinal period possess a heterocyclic nucleus. One of the interesting heterocycles, benzothiazole,
a potent phamacophore, is highly important in the medicinal chemistry due to its association
with diverse pharmacological properties. Development in biological evaluation of heterocyclic molecule
has undergone manifold changes and the advancement in molecular biology has eased the design
of new molecule based on their mechanism of action.
Methods: A structured search of bibliographic databases for peer-reviewed research literature has been
done using different database. The quality of retrieved papers was appraised using standard tools. The
details of important papers were described to focus on the potency of derivatives of benzothiazole.
Results: One hundred fourteen papers were included in the review indicating importance of benzothiazole
derivatives. The review has been focussed on papers highlighting anticancer and antimicrobial activities.
Several papers have been searched for anticonvulsant, anti-inflammatory, antitubercular and
other miscellaneous activities.
Conclusion: The findings of this review confirm the importance of a conceptual framework for widespread
use of heterocyclic compounds containing nitrogen, sulfur and oxygen compounds. It is basically
focused on the medicinal applications of benzothiazole derivatives in the recent years that are
currently attributed to exploitation of drug design and discovery of biologically active compounds
across a wide range of therapeutic areas on a reasonable time scale