Benzothiazole: A Versatile and Multitargeted Pharmacophore in the Field of Medicinal Chemistry

Author(s): Shikha Agarwal, Divyani Gandhi*, Priyanka Kalal

Journal Name: Letters in Organic Chemistry

Volume 14 , Issue 10 , 2017

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Graphical Abstract:


Background: Heterocycles are the gold mines in medicinal chemistry. Most drugs used in today's medicinal period possess a heterocyclic nucleus. One of the interesting heterocycles, benzothiazole, a potent phamacophore, is highly important in the medicinal chemistry due to its association with diverse pharmacological properties. Development in biological evaluation of heterocyclic molecule has undergone manifold changes and the advancement in molecular biology has eased the design of new molecule based on their mechanism of action.

Methods: A structured search of bibliographic databases for peer-reviewed research literature has been done using different database. The quality of retrieved papers was appraised using standard tools. The details of important papers were described to focus on the potency of derivatives of benzothiazole.

Results: One hundred fourteen papers were included in the review indicating importance of benzothiazole derivatives. The review has been focussed on papers highlighting anticancer and antimicrobial activities. Several papers have been searched for anticonvulsant, anti-inflammatory, antitubercular and other miscellaneous activities.

Conclusion: The findings of this review confirm the importance of a conceptual framework for widespread use of heterocyclic compounds containing nitrogen, sulfur and oxygen compounds. It is basically focused on the medicinal applications of benzothiazole derivatives in the recent years that are currently attributed to exploitation of drug design and discovery of biologically active compounds across a wide range of therapeutic areas on a reasonable time scale

Keywords: Benzothiazole, anticancer, antimicrobial, anti-inflammatory, anticonvulsant, anti-tubercular activity.

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Article Details

Year: 2017
Published on: 02 November, 2017
Page: [729 - 742]
Pages: 14
DOI: 10.2174/1570178614666170707160654
Price: $65

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