Background: Cisplatin is one the most frequently used chemotherapeutic drugs for several
decades. Although its antineoplastic effect has been reported in treatment of numerous malignances,
various adverse effects seem to be the crucial limiting factor for its administration.
Objective: Beside the most commonly described nephro- and hepatotoxicity, cisplatin therapy is also
accompanied with gastrointestinal, reproductive, hematological, cardiovascular and neurological side
effects. Since it has been reported that cisplatin induce oxidative damage in various tissues, it seems reasonable
to investigate an antioxidant supplementation as potential therapeutical approach for attenuation
of cisplatin toxicities.
Methods: We performed a structured search of bibliographic databases for research literature using a
focused review question and inclusion/exclusion criteria. The quality of retrieved papers (101 in total)
was appraised using standard tools.
Results: Numerous antioxidants (such as thiol compounds, polyphenols, vitamins, etc.) had been reported
for their beneficial effects on cisplatin-induced cardiotoxicity. The effects of various antioxidants, including
sulfur-containing amino acids, have also been explored for mitigation of cisplatin neurotoxicity.
However, the results for antioxidant supplementation in reduction of cisplatin-induced toxicities are still
to be applied in clinical trials.
Conclusion: Considering the facts that sulfur-containing amino acids: (a) do not interfere with chemotherapeutics
antitumor action; (b) do not exhibit any toxic effect (unless applied in dose several times
above the recommended); and (c) produce significant protective effects on some cisplatin-induced toxicities
connected to augmentation of oxidative damage - it seems that their administration can be harmless
and protective supplementation against numerous adverse effects of certain antineoplastic agents.