Background: Quinazoline refers to the class of condensed ring aromatic organic compounds
of the heterocyclic series containing benzene ring fused to pyrimidine nucleus. A wide range of biologically
active compounds containing quinazoline ring system have also been synthesized by some of the
environmental friendly, so called green methods such as synthesis by means of microwave-irradiation reactions,
and multi component reactions (MCR) in water under microwave irradiation etc.
Methods: The present review article describes synthesis of various derivatives of quinazoline by atomefficient,
eco-friendly, solvent-free, high yielding, multicomponent green strategies reported in the literature.
Results: These procedures reported in the literature and presented here are compatible with different
Conclusion: This review article summarizes the recent advances in the synthesis and biological activity
investigations of quinazoline derivatives.