Background: Many methods have been reported for the determination of ceftazidime such as
liquid chromatography, spectrophotometry and electrochemical methods. Among these methods, electrochemical
methods have their unique advantages such as rapidity, low cost and simplicity.
Methods: In this work, electrochemical technique was used for the determination of ceftazidime using a
carbon nanotube modified electrode. Sodium dodecyl benzene sulphonate (SDBS) was used to enhance
the electrochemical response. Experimental parameters including accumulation time, concentration of
SDBS and solution pH, were optimized for ceftazidime detection.
Results: The carbon nanotube showed good electrocatalytic activity to the ceftazidime oxidation. The
peak current of ceftazidime was greatly increased by SDBS. The detection linear range of this method
was 2 to 55 µM and the detection limit was 0.11 µM.
Conclusion: The modified electrode in this work was simple to fabricate and it was used for the determination
of ceftazidime in ceftazidime vial.