Solvent-Free Synthesis of Thiobarbituric Acids Using Amberlyst-15 as a Green Catalyst

Author(s): Manish M. Katiya, Madhukar G. Dhonde*, Jayant M. Gajbhiye

Journal Name: Current Green Chemistry

Volume 4 , Issue 1 , 2017


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Abstract:

Background: Solvent-free reaction for the synthesis of thiobarbituric acids (TBAs) by the reaction of 1,3-disubstituted thioureas and malonyl chloride using Amberlyst-15 as a green catalyst has been reported. Recyclability of the catalyst was possible up to five runs without loss of catalytic activity.

Conclusion: The simple workup, isolation without column, excellent yields, is main advantages of present protocol.

Keywords: Thioureas, malonyl chloride, thiobarbituric acid, recyclability, amberlyst-15, plausible mechanism.

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Article Details

VOLUME: 4
ISSUE: 1
Year: 2017
Published on: 29 August, 2017
Page: [50 - 56]
Pages: 7
DOI: 10.2174/2213346104666170704115006
Price: $25

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