Abstract
Polyamines are essential for many biological processes in all organisms. Here we show a current landscape of studies and strategies implemented for the study of polyamine metabolism, as well as molecular aspects that implicate the role of key enzymes, transport proteins, inhibitors, and the study of novel molecules as potential therapeutic targets. This review focused on the synthesis, interconversion and function of these molecules in Trichomonas vaginalis, a common sexually transmitted parasite of humans.
Keywords: Hypusination machinery, ornithine decarboxylase (ODC), polyamines, polyamine oxidase (PAO), putrescine, spermine, spermidine, Trichomonas vaginalis.
Current Pharmaceutical Design
Title:Polyamine Transport and Synthesis in Trichomonas vaginalis: Potential Therapeutic Targets
Volume: 23 Issue: 23
Author(s): Maria Elizbeth Alvarez-Sanchez, Jose Luis Villalpando, Laura Itzel Quintas-Granados and Rossana Arroyo*
Affiliation:
- R.A. Av. IPN # 2508, Col. San Pedro Zacatenco, Delg. Gustavo A. Madero, CP 07360, Mexico, D.F,Mexico
Keywords: Hypusination machinery, ornithine decarboxylase (ODC), polyamines, polyamine oxidase (PAO), putrescine, spermine, spermidine, Trichomonas vaginalis.
Abstract: Polyamines are essential for many biological processes in all organisms. Here we show a current landscape of studies and strategies implemented for the study of polyamine metabolism, as well as molecular aspects that implicate the role of key enzymes, transport proteins, inhibitors, and the study of novel molecules as potential therapeutic targets. This review focused on the synthesis, interconversion and function of these molecules in Trichomonas vaginalis, a common sexually transmitted parasite of humans.
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Cite this article as:
Alvarez-Sanchez Elizbeth Maria , Villalpando Luis Jose , Quintas-Granados Itzel Laura and Arroyo Rossana *, Polyamine Transport and Synthesis in Trichomonas vaginalis: Potential Therapeutic Targets, Current Pharmaceutical Design 2017; 23 (23) . https://dx.doi.org/10.2174/1381612823666170703162754
DOI https://dx.doi.org/10.2174/1381612823666170703162754 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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