Background: Polyhydroquinoline derivatives are known as one of the most significant class
of biologically active heterocycles. Herein, in this paper, magnetite polycitric acid (Fe3O4@PCA)
nanoparticles as novel, efficient and reusable catalysts were used for the preparation of polyhydroquinoline
Method: Using aromatic and heteroaryl aldehydes with dimedone, ammonium acetate and ethyl acetoacetate,
polyhydroquinoline derivatives could be synthesized under solvent-free microwave irradiation
condition by Hantzsch multi-component reactions.
Results: Polyhydroquinoline derivatives were prepared under optimized reaction conditions in excellent
yield (97%). The reaction mechanism has been investigated.
Conclusion: This method has the advantages of short reaction times, use of an economically convenient
catalyst, and excellent product yields. Furthermore, the catalyst could be recycled and average
chemical yield for seven consecutive runs was 92%, without any significant reduction of activity.