Title:Experiences with 99mTc-HMPAO in a Diagnostic Pathway for Violent Patients with Schizophrenic Spectrum Disorders
VOLUME: 10 ISSUE: 2
Author(s):Morten Jacobsen*, Arvid Jensen, Guttorm Breivik Storvestre, Tone Marie Bergstrom, Diyar Nori Mohamad Rashi, Bjorn Nielssen , Pal Wiktor and Knut-Erik Hymer
Affiliation:University of Oslo, Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Postbox 1171 Blindern 0318, Oslo, Sykehuset Ostfold, Department of Psychiatry, Postbox 300, 1714 Grålum, Sykehuset Ostfold, Department of Psychiatry, Postbox 300, 1714 Grålum, Sykehuset Ostfold, Department of Psychiatry, Postbox 300, 1714 Grålum, Sykehuset Ostfold, Department of Psychiatry, Postbox 300, 1714 Grålum, Sykehuset Ostfold, Department of Psychiatry, Postbox 300, 1714 Grålum, Sykehuset Ostfold, Department of Psychiatry, Postbox 300, 1714 Grålum, Sykehuset Ostfold, Department of Psychiatry, Postbox 300, 1714 Grålum
Keywords:SPECT, Schizophrenia spectrum disorder, brain perfusion, violence, forensic psychiatry.
Abstract:Background and Objective: In a security ward we assessed the diagnostic contribution
of single photon scintigraphy [SPECT] in our diagnostic pathway for patients with serious mental
disease and a history of violence.
Methods: Twenty patients were examined between 2012 and 2015 and the findings compared to
those in nine patients with the same diagnosis, but no history of violence.
Results: All violent patients had areas with reduced accumulation of
99mTc-HMPAO frontally and
in the temporal lobe, in the non-violent group only two patients demonstrated these findings.
Conclusion: Traditionally, low accumulation of the tracer in SPECT is related to reduced perfusion
of brain tissue. We discuss our findings in the light of other possible pathophysiological
mechanisms.
