Background: Up to date, numerous attempts for the synthesis of potentially interesting medicinally
important heterocyles and organic compounds by application of a wide range of homogeneous
and heterogeneous catalysts under green conditions have been made and published. The abundance and
variety of diseases and the needs of mankind for treatment of them have made these attempts inevitable.
Furthermore, among highly active catalysts, nano-sized Lewis acids play an outstanding role in
organic synthesis. Considering all the above facts, herein, numerous potentially interesting biologically
active organic products have been synthesized and reported by the use of magnetic iron oxide nanoparticles
under green conditions with good to excellent yields.
Methods: An efficient and environmentally adapted synthetic route to tri-substituted methanes syntheses
by the use of Fe3O4 nanoparticles as a green and recyclable Lewis acid catalyst is introduced. The
chemical structures of all obtained products were deduced and confirmed by their 1H NMR, 13C NMR,
IR spectroscopies, and elemental analyses (C, H, N, S).
Results: In this study, magnetic iron oxide nanoparticles (Fe3O4 NPs) as an highly efficient, recyclable
and eco-friendly heterogeneous Lewis acid catalyst have been successfully applied to the green and
promoted synthesis of a newly prepared type of tri-substituted methane derivatives containing 4-
hydroxycoumarin, arylaldehydes, and N,N-dimethylbarbituric acid under mildly solvent-free conditions
via a Domino reaction. In some cases, condensed products via Knoevenagel coupling reaction are
only obtained under given conditions. This procedure using Fe3O4 NPs has some advantages synthetically
and from industrially point of view including obtaining excellent yields of products, short reaction
times, green and safety protocol, ease of handling, and capability of catalyst for reuse.
Conclusion: By this achievement, the scope of organic products and potentially biological active compounds
has been developed. One-pot synthesis of products under green conditions using reusable magnetic
Fe3O4 nanoparticles as catalyst with high yields could attract the interests of chemists and industrialists.
In addition, the presence of 4-hydroxycoumarin and N,N-dimethylbarbituric acid scaffolds as
important biological and pharmacological fragments in the chemical structure of products makes them
more significant for pharmacologists, and their biological and pharmacological activities could be
evaluated in future.