Background: Sclerostin (SOST) is a secretary product of osteocytes and it is a
glycoprotein expressed by SOST gene. It is well studied and established that sclerostin inhibits
the bone formation by blocking Wnt signaling pathway. SOST gene acts as a potential
therapeutic target for treating autosomal disorders, like van Buchem disease and sclerosteosis.
Bioinformatics analysis of SOST gene shall provide exhaustive insights into the
evolutionary origin of the gene sequence and its functional characteristics.
Objective: In this review, we focus on presenting comprehensive information on SOST
gene, its regulation and its role in van Buchem disease and sclerosteosis along with insilico
analyses of its sequences.
Method: The review on SOST gene and its mediation was done using various reports already
published and other online resources. Bioinformatics tools and database such as
BioGPS, Uniprot, MEGA and STRING were used for sequence analysis.
Results: An overview on the regulation of SOST gene, its inhibitors and their pharmacological
effects is presented. The molecular phylogenetic study and functional characterization
suggested the conservation of SOST sequences among various species and the molecular
pathway associated with SOST.
Conclusion: The mediation of SOST gene under normal and disease conditions has hinted
it as a potential therapeutic target, which is further confirmed through bioinformatics approaches.
This paves way to attempt a possible regulation of SOST gene action involving
peptide / peptidomimetic molecules and charged nanoparticles, especially during orthodontic