2-Alkynoates are important unsaturated carbonyl compounds showing a large
application as intermediates in organic synthesis. Despite wide importance of these compounds
in synthetic chemistry, very few synthetic methods have been reported till date. In
recent years much effort has been made to develop the carboxylative coupling of terminal
alkynes, organohalides and carbon dioxide to provide the 2-alkynoate derivatives. Good
yields, high atom and step economy, and readily available substrates are the key features
of this page of 2-alkynoate synthesis. This review article is an attempt to survey literature
describing synthetic methods for the preparation of 2-alkynoate derivatives through the
three-component reaction of terminal alkynes, organohalides and CO2.
Keywords: 2-Alkynoates, carbon dioxide, carboxylative coupling, three-component reactions, copper, silver.
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