Background: Clomiphene is normally used in women with ovulatory dysfunction. In men, it
is used off label in some cases of infertility. Psychological adverse effects are reported in women but
very few in men.
Case: A 34-year-old man treated with clomiphene for oligoteratospermia presented anxiety, decreased
appetite, and mood change making him unable to function properly at work, five days after initiation of
therapy. Symptoms required reduction followed by discontinuation of treatment four days later because
of absence of improvement. Following cessation, the patient noted a gradual then a complete resolution
approximately one week later. The patient did not have any psychiatric or other medical condition
neither drug nor substance abuse that could explain this clinical presentation. The Naranjo's score was
used to prove the clomiphene's imputability.
Conclusion: Health care providers should advise patients of the risk of psychological adverse effects
when initiating treatment with clomiphene and should provide a close monitoring of mood change,
especially during the initial weeks.