Introduction: Incidence of antibiotic- associated diarrhoea is a common (10–30%) but
pseudomembranous colitis (PMC) is less frequent (1-5%). Fluoroquinolones, clindamycin, penicillins,
cephalosporins (mostly third generation) are commonly associated with PMC. The association between
cephalosporins and PMC is now well established.
Case Presentation: A 78 year old male patient developed pseudomembraneous colitis after
administration of Ceftriaxone and Cefazoline for the treatment of pleural effusion. The reaction was
confirmed by ultrasonography and CT scan. Causative agents were stopped and patient was managed by
systemic therapy. Patient was expired due to respiratory complications as there was complexity in
management of disease due to development of pseudomembraneous colitis.
Conclusion: Increase awareness of prescribers for high-risk drugs, close monitoring, with immediate
withdrawal of the culprit drug can reduce the complexity of management that occur due to development
of such adverse drug reaction.