Abstract
Background: Hydroxamic acids are a major class of organic compounds. They have a wide variety of pharmacological actions in targeting cancers, cardiovascular diseases, HIV, Alzheimer's disease, Malaria, Allergic diseases.
Objective: The present review focuses on the chemistry of conventional and non-conventional routes for the synthesis of hydroxamic acids reported till date.
Conclusion: The hydroxamic acids are conventionally synthesized via carboxylic acid and their acid chloride derivatives. However, some other functional groups i.e. aldehyde, amine, amide and alcohol can also be converted to hydroxamate with ease. The solid phase synthesis techniques are also gaining importance for the synthesis of hydroxamic acids and these pathways have opened a wide arena for the synthesis of diverse and complex hydroxamic acids.
Keywords: Hydroxamic acid, aldehyde, carboxylic acid, amide, alcohol, synthesis.
Current Organic Synthesis
Title:Strategies for the Synthesis of Hydroxamic Acids
Volume: 15 Issue: 2
Author(s): Ankit Ganeshpurkar, Devendra Kumar and Sushil K. Singh*
Affiliation:
- Pharmaceutical Chemistry Research Lab-1, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi- 221005, U.P.,India
Keywords: Hydroxamic acid, aldehyde, carboxylic acid, amide, alcohol, synthesis.
Abstract: Background: Hydroxamic acids are a major class of organic compounds. They have a wide variety of pharmacological actions in targeting cancers, cardiovascular diseases, HIV, Alzheimer's disease, Malaria, Allergic diseases.
Objective: The present review focuses on the chemistry of conventional and non-conventional routes for the synthesis of hydroxamic acids reported till date.
Conclusion: The hydroxamic acids are conventionally synthesized via carboxylic acid and their acid chloride derivatives. However, some other functional groups i.e. aldehyde, amine, amide and alcohol can also be converted to hydroxamate with ease. The solid phase synthesis techniques are also gaining importance for the synthesis of hydroxamic acids and these pathways have opened a wide arena for the synthesis of diverse and complex hydroxamic acids.
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Cite this article as:
Ganeshpurkar Ankit , Kumar Devendra and Singh K. Sushil *, Strategies for the Synthesis of Hydroxamic Acids, Current Organic Synthesis 2018; 15 (2) . https://dx.doi.org/10.2174/1570179414666170614123508
DOI https://dx.doi.org/10.2174/1570179414666170614123508 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
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