Molecular Modeling Interaction Between Enzyme Diabetes Type 2 Dipeptidyl- Peptidase (DPP-4) and Main Compound of Cinnamon

Author(s): Bouchentouf Salim*, Ghalem Said, Missoum Noureddine, Allali Hocine

Journal Name: Current Enzyme Inhibition

Volume 14 , Issue 1 , 2018

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Graphical Abstract:


Background: Nowadays molecular modeling is widely used in different areas of scientific research. Especially in medical and pharmaceutical research molecular modeling allows saving time and money in conception of new drugs by comprehension of interaction between disease's enzymes and inhibitors for probable formation of stable complex. Cinnamon as famous plant and culinary spice is highly recommended in treatment of type 2 diabetes by many researchers.

Methods: By molecular modeling and molecular docking, interactions between type 2 diabetes enzyme (DPP-4) and characteristically molecules of cinnamon are studied.

Results: Molecules from different parts of cinnamon interact differently with diabetes type 2 enzyme (DPP-4) and confirm primary studies concerning cinnamon anti-diabetic effect.

Conclusion: Buds and flowers molecules of cinnamon inhibit DPP-4 enzyme better than barks commonly used as spices and traditional medicines.

Keywords: Cinnamon, diabetes, DPP4, inhibitor, MOE (Molecular Operating Environment), molecular modeling.

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Article Details

Year: 2018
Page: [61 - 66]
Pages: 6
DOI: 10.2174/1573408013666170613103142
Price: $65

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PDF: 26
PRC: 1