Background: Scleroderma is a term used to describe diseases that involve hardening and
tightening of the skin and the underlying subcutaneous connective tissue. It could be localized to
skin and subcutaneous tissue, or may involve the internal organs too in systemic sclerosis.
Objective: There are disorders that can cause hardening and tightening of skin and mimic
scleroderma but are rarely associated with Raynaud phenomenon, sclerodactyly, and autoantibodies
in the serum, features specific to scleroderma/systemic sclerosis.
Conclusion: These are termed as “scleroderma variants” or “scleroderma like disorders”. This review
discusses the various “scleroderma variants” e.g. scleromyxedema, scleredema, nephrogenic
systemic fibrosis, and eosinophilic fasciitis.