Objective: To evaluate the correlation between smoking and types of coronary atherosclerotic
plaques using Double-Source Computed Tomography (DSCT) angiography.
Methods: Patients who underwent DSCT Coronary Angiography (DSCTCA) at our hospital between
April 2012 and April 2013 were enrolled and divided into a smoking group and a nonsmoking
group according to their response to a questionnaire of smoking. Patients with a familial
genetic history of coronary or concomitant diabetes mellitus, hypertension, or hyperlipidemia were
considered and divided into two groups according to their smoking history, as 200 smokers and
200 non-smokers were selected for the study. The incidence rates, distribution characteristics, and
types of plaque were identified and compared between the two groups.
Results: The incidences of mixed plaques (44.7% vs. 21.9%) and non-calcified plaques (38.7% vs.
67.9%) were significantly different between the smoking group and the non-smoking group (both
P <0.05). When the data were adjusted for age, sex, and weight index, smoking was an independent
risk factor for formation of mixed plaques. The smoking group was subdivided according to the
Smoking Index (SI) and a comparison showed that the incidence of mixed plaques increased with
Conclusion: DSCTCA can accurately evaluate differences in coronary atherosclerotic plaques between
smokers and non-smokers. Smokers are more likely to develop mixed plaques and are at
higher risk of cardiovascular events, and the plaques are distributed more widely.