Sarcopenia, the progressive and generalized loss of skeletal muscle mass and
strength/function associated with aging, increases the risk of a vast array of adverse health outcomes,
including falls, morbidity, loss of independence, disability, and mortality. As such, sarcopenia poses a
huge socioeconomic burden in developed countries. The development and implementation of effective
interventions against sarcopenia are therefore a public health priority. A preliminary, fundamental
step in such a process entails the agreement of researchers, healthcare professionals and policymakers
around a unique operational definition of sarcopenia. This will facilitate the framing of a clear
clinical entity to be incorporated in standard practice, the understanding of the underlying pathophysiology,
and the identification of biological targets for drug development.
Keywords: Exercise, frailty, gait speed, muscle mass, muscle strength, operational definition, physical performance, protein.
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