Sarcopenia: An Overview on Current Definitions, Diagnosis and Treatment

Author(s): Francesco Landi*, Riccardo Calvani, Matteo Cesari, Matteo Tosato, Anna Maria Martone, Elena Ortolani, Giulia Savera, Sara Salini, Alex Sisto, Anna Picca, Emanuele Marzetti

Journal Name: Current Protein & Peptide Science

Volume 19 , Issue 7 , 2018

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Graphical Abstract:


Sarcopenia, the progressive and generalized loss of skeletal muscle mass and strength/function associated with aging, increases the risk of a vast array of adverse health outcomes, including falls, morbidity, loss of independence, disability, and mortality. As such, sarcopenia poses a huge socioeconomic burden in developed countries. The development and implementation of effective interventions against sarcopenia are therefore a public health priority. A preliminary, fundamental step in such a process entails the agreement of researchers, healthcare professionals and policymakers around a unique operational definition of sarcopenia. This will facilitate the framing of a clear clinical entity to be incorporated in standard practice, the understanding of the underlying pathophysiology, and the identification of biological targets for drug development.

Keywords: Exercise, frailty, gait speed, muscle mass, muscle strength, operational definition, physical performance, protein.

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Article Details

Year: 2018
Page: [633 - 638]
Pages: 6
DOI: 10.2174/1389203718666170607113459
Price: $65

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