Introduction: The ever-evolving field of gene therapy promises several innovative treatments
for cancer. Advances in genetic modification of tumor cells and micro environment have led to
the development of more effective therapeutic strategies with fewer side effects.
Materials & Methods: The development of effective delivery system challenges, remains. Non-viral
vectors are interesting due to their bio-safety and their ability to transfer different types of nucleic acids.
Examples of these techniques are the use of oligonucleoides, liposomes, nanoparticles, inorganic
material, and engineered stem cells.
Conclusion: In this review, we focus on recent advances in the intracellular delivery of DNA and
siRNA to the cancer cells with emphasis on breast cancer.