Abstract
Introduction: The ever-evolving field of gene therapy promises several innovative treatments for cancer. Advances in genetic modification of tumor cells and micro environment have led to the development of more effective therapeutic strategies with fewer side effects.
Materials & Methods: The development of effective delivery system challenges, remains. Non-viral vectors are interesting due to their bio-safety and their ability to transfer different types of nucleic acids. Examples of these techniques are the use of oligonucleoides, liposomes, nanoparticles, inorganic material, and engineered stem cells. Conclusion: In this review, we focus on recent advances in the intracellular delivery of DNA and siRNA to the cancer cells with emphasis on breast cancer.Keywords: Breast cancer, Non-viral delivery system, APTAMER, Gene therapy, DNA, RNA.
Current Gene Therapy
Title:Non-viral Delivery Systems for Breast Cancer Gene Therapy
Volume: 17 Issue: 2
Author(s): Golnaz Vaseghi, Laleh Rafiee and Shaghayegh Haghjooy Javanmard*
Affiliation:
- Applied Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan,Iran
Keywords: Breast cancer, Non-viral delivery system, APTAMER, Gene therapy, DNA, RNA.
Abstract: Introduction: The ever-evolving field of gene therapy promises several innovative treatments for cancer. Advances in genetic modification of tumor cells and micro environment have led to the development of more effective therapeutic strategies with fewer side effects.
Materials & Methods: The development of effective delivery system challenges, remains. Non-viral vectors are interesting due to their bio-safety and their ability to transfer different types of nucleic acids. Examples of these techniques are the use of oligonucleoides, liposomes, nanoparticles, inorganic material, and engineered stem cells. Conclusion: In this review, we focus on recent advances in the intracellular delivery of DNA and siRNA to the cancer cells with emphasis on breast cancer.Export Options
About this article
Cite this article as:
Vaseghi Golnaz, Rafiee Laleh and Javanmard Haghjooy Shaghayegh*, Non-viral Delivery Systems for Breast Cancer Gene Therapy, Current Gene Therapy 2017; 17 (2) . https://dx.doi.org/10.2174/1566523217666170606124131
DOI https://dx.doi.org/10.2174/1566523217666170606124131 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
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