Background: Rheumatoid arthritis (RA) and migraine are both common disorders which
are caused by a faulty immune system and autonomic nervous system dysfunction, respectively.
Although current treatment outlook has shown a great improvement in these two diseases, however
many side effects have been reported.
Case Report: We reported a case of 43-years-female that has suffered from rheumatoid arthritis for
3 years with a 6 years history of migraine. She had used different types of medication for both
rheumatoid arthritis and migraine but during these 6 years no improvement had been observed and
even migraine progression in this patient became worse. She was admitted to the hospital for 12
weeks follow-up to evaluate the effect of β-D-mannuronic acid (M2000) on her RA disease.
Materials and Methods: During 12 weeks of M2000 therapy, the signs and symptoms of migraine
along with RA indices including Disease Activity Score (DAS28), simple disease activity index
(SDAI) and C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor
(RF), anti-cyclic citrullinated peptide antibodies (anti-CCP) and blood determinants were measured.
Results and Discussion: The patient achieved a strong clinical improvement after 12 weeks of
M2000 therapy in DAS28, SDAI and laboratory parameters. Moreover, M2000 showed a significant
effect on the severity and the duration of migraine pain as well as times of migraine attack. In
the present case, both rheumatoid arthritis and migraine as two different inflammatory diseases
were diagnosed. Therefore, reducing the inflammation could be a valuable target to decrease the
signs and symptoms of migraine and rheumatoid arthritis and help to the treatment process.
Conclusion: M2000 as a novel designed non-steroidal anti-inflammatory drug (NSAID) with immunosuppressive
property is able to treat migraine in addition to its potent efficacy on treatment of