Background: Obesity is a global epidemic throughout the world. There is thus
increasing interest in searching for natural bioactive compounds with anti-obesity effect.
A number of marine compounds have been regarded as potential sources of bioactive
compounds and are associated with an anti-obesity effect.
Objective: Marine-derived compounds with anti-obesity effect and their current applications,
methods and indicators for the evaluation of anti-obesity activity are summarized in
this review. in order to make contributions to the development of marine-derived functional
food against obesity.
Results: In this review, an overview of marine-derived compounds with anti-obesity effect,
including marine polysaccharides, marine lipid, marine peptides, marine carotenoids
is intensively made with an emphasis on their efficacy and mechanism of action. Meanwhile,
methods and indicators for the evaluation of anti-obesity activity are discussed. We
summarize these methods into three categories: in vitro assay (including adsorption experiments
and enzyme inhibitory assay), cell line study, animal experiments and clinical
experiments. In addition, a brief introduction of the current applications of marine bioactive
compounds with anti-obesity activity is discussed.
Conclusion: Marine environment is a rich source of both biological and chemical diversity.
In the past decades, numerous novel compounds with anti-obesity activity have been
obtained from marine organisms, and many of them have been applied to industrial production
such as functional foods and pharmaceuticals. Further studies are needed to explore
the above-mentioned facts.