High Sensitivity Troponin I and T Reflect the Presence of Obstructive and Multi-Vessel Coronary Artery Disease Being Assessed by Coronary Computed Tomography Angiography

Author(s): Nadine Reckord, Michael Behnes*, Michèle Natale, Agnibh Mukherji, Jonas Rusnak, Uzair Ansari, Siegfried Lang, Ursula Hoffmann, Martin Borggrefe, Thomas Henzler, Michael Neumaier, Maximilian T. Kittel, Kambis Mashayekhi, Thomas Bertsch, Ibrahim Akin.

Journal Name: Current Pharmaceutical Biotechnology

Volume 18 , Issue 6 , 2017

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Graphical Abstract:


Background: This study evaluates the association between high sensitivity troponin I (hsTnI) and T (hsTnT) in patients with suspected stable Coronary Artery Disease (CAD) undergoing Coronary Computed Tomography Angiography (CCTA).

Methods: Patients undergoing CCTA were enrolled prospectively. CCTA was indicated in patients with angina and a low to intermediate pre-test probability for CAD during routine clinical care. Blood samples were taken at the time of CCTA to measure cardiac biomarkers.

Results: A total of 99 patients were enrolled with 43 % revealing no CAD, 30 % with non-obstructive and 26 % with obstructive CAD. Out of these, 61 % had single-vessel and 39 % had multi-vessel CAD. Both hsTnI and hsTnT levels increased significantly according to the presence and extent of CAD (p = 0.0001) and were able to discriminate the presence of both obstructive (AUC range: 0.775 - 0.785; p = 0.0001) and multi-vessel CAD (AUC range: 0.740 - 0.749; p = 0.01). In multivariate logistic regression models adjusted for cardiovascular risk factors and NT-proBNP, both hsTn were still associated significantly with obstructive CAD (range of odds ratios (OR): 8.3-32.3; p < 0.02).

Discussion: This study shows that high sensitivity troponin I and T reflect the presence and extent of CAD being diagnosed by CCTA in patients with a low to intermediate pretest probability for CAD.

Keywords: Blood sampling, computed tomography, coronary artery disease, high sensitivity troponin, data analysis.

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Article Details

Year: 2017
Page: [508 - 515]
Pages: 8
DOI: 10.2174/1389201018666170601082145
Price: $65

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